For their study, the researchers used a strain of Acinetobacter baumannii isolated from a wounded Canadian soldier returning from Afghanistan to laboratory tests. They found that A3-APO, when given intramuscularly, is less toxic and more effective in reducing bacterial count in the blood and the site of injury imipenem or colistin. The peptide also protected open wounds by a bacterial infection of the environment.?This is the first peptide is more effective in an animal model of anything else that is available,? said ?tv?s, who hopes the peptide can be tested in clinical trials in the near future.
Their findings are published in the Journal of Antimicrobial Chemotherapy.
When pregnant women need medication, there are often concerns about possible effects on the fetus. Although some drugs are clearly known to cause birth defects , and others are generally recognized as safe, surprisingly little is known about the level of most of the risks of drugs?. Researchers at Children?s Hospital Informatics Program Boston have created a preclinical model provides a drug teratogenicity based on the characterization of target genes.
An antibacterial peptide developed by Laszlo ?tv?s, a research professor of biology at the College Hall of Science and Technology, which seems to be a highly effective therapy against infections caused by burns or blast soldiers.
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